Frost & Sullivan, in collaboration with Chuangjian Medical, has globally released the 'Nucleic Acid Tetrahedron Blue Book' (with full-text access available)

Qian Song, Chairman of Chuangjian Medical, delivered a speech as the organizer of the conference. He stated that nucleic acids and proteins are the two most important components for cell anti-aging. To achieve comprehensive anti-aging, Chuangjian Medical began its layout in the fields of recombinant collagen and nucleic acids as early as 2016 and 2019, and launched a series of products including Type I, II, III, XVII recombinant collagen and biosynthetic nucleic acid tetramers. Chuangjian Medical uses advanced synthetic biology techniques to reduce the production cost of nucleic acid tetramers, shorten their production cycle, and make nucleic acid tetramers a high-tech raw material that most cosmetic brands can afford, opening up new markets for the large-scale application of nucleic acid tetramers.

Chairman of Chuangjian Medical, Qian Song

Li Qian, consulting director of Frost & Sullivan's Life Sciences business unit in Greater China, stated at the release ceremony that nucleic acid tetramers possess low immunogenicity, high biocompatibility, and promote skin tissue regeneration. These characteristics make them have broad application prospects in serious medical care, medical aesthetics, efficacy skincare, and other fields. The release of the 'Nucleic Acid Tetramers Blue Book' will further assist the public in understanding this emerging field. At the same time, the English version of the 'Nucleic Acid Tetramers Blue Book' has also been released synchronously on the Frost & Sullivan global official website, helping outstanding Chinese enterprises in the nucleic acid tetramers field enter the global market.

Li Qian, Consulting Director of Life Sciences Business Unit, Frost & Sullivan Greater China Region

The 'Nucleic Acid Tetrahedron Blue Book' starts from the basic concepts of nucleic acids, systematically introducing their types, history, naming, and molecular structure, laying a foundation for understanding the innovative applications of tFNA. The report focuses on discussing the unique structural characteristics of tFNA, including its high mechanical strength, stability, editability, as well as good biocompatibility and safety. It elaborates in detail on the broad application prospects of tFNA's unique advantages in areas including skin, bone tissue, nervous system, immune system, and antibacterial therapy.

The following is an excerpt from the Blue Book. For detailed content, scan the QR code to obtain the full version:

Nucleic acids are crucial biological macromolecules in cells and viruses. They undertake important tasks within the cell such as producing, encoding, and storing genetic information, and transmit and express these life instructions both inside and outside the cell nucleus. From the delicate operations within cells to the reproduction of organisms, nucleic acids convey life information through their base sequences. This sequence arrangement gives RNA and DNA a unique 'stepped' nucleotide structure. These two types of nucleic acids play an indispensable role in guiding protein synthesis and are essential molecular commanders in life activities.

DNA molecules are one of the most unique molecules in nature due to their highly predictable and programmable interactions. They are known for their excellent binding specificity and thermodynamic stability, capable of reliably binding to their complementary strands through almost infinite sequence selection. At the nanoscale, DNA structures are precise and well-defined. Automated techniques can rapidly synthesize and modify them, and the application of various DNA enzymes makes further adjustments and modifications to their structures controllable.

The field of DNA nanotechnology focuses on using the molecular properties of deoxyribonucleic acid (DNA) or other nucleic acids to construct controllable new nanoscale structures or machines. In this field, nucleic acids are used as non-biological materials rather than carriers of genetic information. Although DNA is a commonly used material, other nucleic acids such as ribonucleic acid (RNA) and peptide nucleic acid are also used for structural construction, and therefore the field is sometimes referred to as 'nucleic acid nanotechnology'.

Among numerous DNA nanostructures, tetrahedral DNA nanostructures, also known as 'tetrahedral framework nucleic acids' or 'nucleic acid tetrahedra' (Tetrahedral framework nucleic acids, abbreviated as tFNA(s)), stand out for their unique properties. These advantages make them extremely useful in biomedical applications.

1. High mechanical strength: TFNA has high mechanical strength, enabling them to maintain structural integrity in various biological environments.

Second, high stability: tFNA is relatively stable and can maintain its structure even in complex biological environments such as serum, demonstrating good relative serum stability.

III. Editability: TFNA is highly editable. It can be connected to small molecules, peptides, nucleic acids, etc., through various methods such as electrostatic adsorption, sequence extension, and sequence complementarity, thus acting as a carrier in drug delivery and molecular recognition. This multifunctionality enables TFNA to adapt to different biomedical needs.

IV. Good biocompatibility and safety: TFNA has good biocompatibility, which means that they do not cause adverse immune responses or cell damage when interacting with biological systems. This is crucial for ensuring their safety and effectiveness in the body.

V. Easy entry into cells: TFNA is readily able to pass through cell membranes, which is crucial for its use in intracellular drug delivery or gene editing tools. This transmembrane ability enables TFNA to efficiently deliver payloads into target cells, thereby improving treatment efficiency.

From structural-based cell biology regulation to serving as a drug carrier, TFNA exhibits diverse functions. Especially in skin and soft tissue repair, bone tissue regeneration, nervous system protection, immune system regulation, and antibacterial therapy, TFNA demonstrates unique advantages.