On August 4, 2026, at the 20th Frost & Sullivan Global Growth, Innovation and Leadership Summit and the 5th New Investment Conference held in Shanghai, Frost & Sullivan and Shuyin Intelligence Technology jointly released 'A New Era of Precision Gene Skincare Driven by Small Nucleic Acids: White Paper on Application Scenarios of siRNA in Consumer Level Markets', and provided an interpretation of its core research findings.
"A New Era of Precision Gene Skincare Driven by Small Nucleic Acids: White Paper on Application Scenarios of siRNA in Consumer-Level Fields" systematically studies the development path of siRNA in consumer-level applications such as functional skincare, scalp care, and medical beauty from aspects including technological evolution, consumer demand, application scenarios, raw material development, industrial ecosystem, regulatory environment, and future trends.
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As a key research enterprise in this small nucleic acid white paper, Shuyi Intelligence Technology is a technology platform company focused on the research and development of consumer-level siRNA technologies and industrial transformation. Based on an interdisciplinary research team, and relying on an R&D platform that combines AI models with high-throughput wet experiments, Shuyi Intelligence Technology has established a research and development system covering target discovery, molecular design, experimental validation, delivery adaptation, and product transformation. It continues to develop siRNA active ingredients in directions such as whitening, wrinkle prevention, skin sensitivity relief, and oil control. Currently, Shuyi Intelligence Technology has three siRNA ingredients available on the market: the anti-aging siRNA ingredient Kousu Yin®, the whitening siRNA ingredient Ke Bai Yin®, and the skin sensitivity relief siRNA ingredient Yu Yin®. The company has established a diverse brand cooperation ecosystem, with partners including international high-end beauty brands, local leading skin care brands, and emerging functional skin care brands. It has also reached strategic cooperation with many domestic and international top brands. At present, Shuyi Intelligence Technology is accelerating the application of siRNA technology across multiple brands, multiple functions, and various product forms through innovative siRNA ingredient output and exclusive customized ingredient cooperation, promoting the rapid transformation of cutting-edge nucleic acid technology from research achievements into consumer-grade products.
The white paper indicates that at the consumer demand level, skincare products focused on efficacy are shifting from "basic care" to "problem-oriented, evidence-based, and population-specific solutions." Consumers no longer solely focus on whether a popular ingredient is included, but rather on whether the product has a clear mechanism of action, sufficient evidence of effectiveness, and a solution tailored to their skin conditions. Among them, the Gen Z generation, high-net-worth individuals, and ingredient enthusiasts represent three distinct types of needs: exploring new technologies, systematic anti-aging, and rational consideration of mechanisms. The Gen Z generation focuses on the understandability of new technologies and content dissemination; high-net-worth individuals prioritize high-end anti-aging, professional endorsement, and long-term management; while ingredient enthusiasts have evolved from simply checking the ingredient list to examining the mechanism of action, efficacy data, and safety boundaries.
Under this trend, siRNA provides a new technical approach for functional skincare. Compared to traditional active ingredients, siRNA allows molecular design around specific targets, regulating the expression of target proteins through a clear pathway of "target - mRNA - protein - skin phenotype", enabling functional skincare to progress from component combination to target design, mechanism regulation, and systematic validation. The value of siRNA lies not in simply replacing traditional ingredients, but in shifting the development logic of active ingredients from "component addition and final efficacy verification" to "target selection, sequence design, mechanism regulation, and evidence chain verification". By precisely regulating the expression of siRNA-related genes, it enables proactive intervention in skin condition, moving skincare from "remediation after problems occur" to "prevention + full-cycle management".
围绕消费级应用场景，小核酸白皮书系统梳理了siRNA在精准抗衰、美白、敏感肌修护、控油、防脱及医美等方向的应用潜力，并重点拆解了精准抗衰、美白及敏感肌修护三类代表性场景的作用机制。在精准抗衰场景中，抗衰siRNA原料科溯因®可通过靶向相关mRNA，加速胶原降解的相关因子表达以控制下游胶原流失，大大提升肌肤真皮I型和III型胶原含量；在美白场景中，传统路径的不同环节分别存在起效较慢、需建立耐受，或停用后可能返黑等局限，美白siRNA原料科白因®则可通过抑制酪氨酸酶的mRNA表达，直接从黑色素合成上游进行源头调控；在敏感肌修护场景中，抗敏siRNA原料科御因®围绕这一皮肤敏感信号关键开关进行靶向干预，从源头减少敏感反应，7天快速有效减少肌肤泛红60%。不同场景背后均存在可被识别和调控的关键通路，这为siRNA从单一原料创新走向多场景功效方案提供了基础。
siRNA在消费级场景中的应用并不只取决于靶点选择和序列设计，皮肤递送同样是决定其产品化可行性的关键环节。由于siRNA分子天然难以直接穿透皮肤屏障并到达目标作用区域，因此需要依托适配的递送体系，在保障活性稳定性的同时提升皮肤渗透效率、细胞摄取水平和局部作用可控性。小核酸白皮书分析指出，面向护肤、头皮护理和医美修护等消费级场景，皮肤递送技术需要与不同功效靶点、剂型形态和使用场景相匹配，形成从核酸分子设计到终端产品体验的完整转化能力。随着皮肤递送技术、配方体系和功效验证方法持续完善，递送能力将成为RNA功效原料企业从实验室验证走向品牌合作与规模化应用的重要技术壁垒。
At the industrial ecosystem level, the XiaoNucleic Acid White Paper outlined the division of labor in the siRNA cosmetics industry chain: upstream includes nucleic acid raw materials and equipment testing service providers, while midstream companies are primarily siRNA raw material suppliers, responsible for target and sequence design, delivery and formulation conversion, as well as the development and production of active ingredients. The downstream segment involves cosmetic brand owners and OEM/ODM manufacturers who complete the final product transformation. Among these, AI-target screening, sequence design, high-throughput verification, and skin delivery capabilities are the core technical barriers affecting the efficiency of raw material development and product conversion levels. As skincare brands continue to focus more on the mechanisms and innovation of functional skincare ingredients, the cooperation model between skincare brands and siRNA raw material suppliers has gradually evolved from simple raw material procurement to standardized solutions, joint development, and exclusive customization.
展望未来，随着分子设计、皮肤递送、安全验证及规模化生产能力不断成熟，小核酸siRNA功效原料开发企业有望由单一的原料供应商发展为覆盖多靶点、多功效和多场景的核酸活性物平台，并进一步拓展至个性化精准护肤、皮肤健康全周期管理及专业护理等领域。具备平台化研发能力、丰富功效管线和产业协同资源的企业，将更有机会建立长期技术优势，推动siRNA消费级应用加速落地。
